STin2 VNTR polymorphism is associated with comorbid tobacco use and mood disorders
Marcia Regina Pizzo de Castro, Sandra Odebrecht Vargas Nunes, Roberta Losi Guembarovski, Carolina Batista Ariza, Julie Massayo Maeda Oda, Heber Odebrecht Vargas, Luiz Gustavo Piccoli de Melo, Maria Angelica Ehara Watanabe, Michael Berk, Michael Maes
Journal of Affective Disorders | ELSEVIER | Published : 2015
BACKGROUND: There is a significant comorbidity between mood disorders and tobacco use disorder (TUD), which may be related to both genetic and environmental factors. Gene variants of the 5-HT transporter, such as STin2 VNTR (a variable number of tandem repeats in the functional serotonin transporter intron 2) may be associated with mood disorders and TUD. AIMS: This study aimed to delineate the association between the STin2 genetic polymorphism and comorbid TUD and mood disorders, including depression or bipolar disorder. METHODS: We examined the STin2 VNTR polymorphism in never-smokers (n=113); patients with mood disorders without TUD (n=62); patients with TUD without mood disorders (n=90);..View full abstract
Awarded by NHMRC
Awarded by CNPq (Conselho Nacional de Desenvolvimento Cientifico e Technologia)
Awarded by Londrina State University, Londrina, Parana, Brazil
This study was supported by Health Sciences Postgraduate Program at Londrina State University, Parana, Brazil (UEL) and Fundacao Araucaria. MB is supported by a NHMRC Senior Principal Research Fellowship 1059660. MM is supported by a CNPq (Conselho Nacional de Desenvolvimento Cientifico e Technologia) (Grant no. 404877/2013-3) PVE fellowship at the Health Sciences Graduate Program, Londrina State University, Londrina, Parana, Brazil (UEL) (Grant no. 40002012046P0).