Journal article

Clinical Patterns and Outcome of Early-Onset Inflammatory Bowel Disease

Oren Ledder, Anthony G Catto-Smith, Mark R Oliver, George Alex, Donald JS Cameron, Winita Hardikar

Journal of Pediatric Gastroenterology and Nutrition | LIPPINCOTT WILLIAMS & WILKINS | Published : 2014

Abstract

We sought to determine whether extremely-early-onset childhood inflammatory bowel disease (age <6 years; 20 ulcerative colitis [UC], 8 Crohn disease [CD], 2 indeterminate, sequentially diagnosed) was clinically more severe than in older children (6-17 years; 19 UC, 39 CD, 2 indeterminate). Early-onset UC was marked by less abdominal pain at presentation, but an aggressive course with a significant reduction in weight-for-age, increased use of immunosuppressants, and more surgery. Children with early-onset CD were more likely to have bloody stools at presentation and an isolated colitis. This study supports the suggestion that inflammatory bowel disease phenotype differs in early-onset diseas..

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