Journal article
Geographic variation in the eukaryotic virome of human diarrhea
Lori R Holtz, Song Cao, Guoyan Zhao, Irma K Bauer, Donna M Denno, Eileen J Klein, Martin Antonio, O Cohn Stine, Thomas L Snelling, Carl D Kirkwood, David Wang
Virology | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2014
Abstract
Little is known about the population of eukaryotic viruses in the human gut ("virome") or the potential role it may play in disease. We used a metagenomic approach to define and compare the eukaryotic viromes in pediatric diarrhea cohorts from two locations (Melbourne and Northern Territory, Australia). We detected viruses known to cause diarrhea, non-pathogenic enteric viruses, viruses not associated with an enteric reservoir, viruses of plants, and novel viruses. Viromes from Northern Territory children contained more viral families per sample than viromes from Melbourne, which could be attributed largely to an increased number of sequences from the families Adenoviridae and Picornaviridae..
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Awarded by National Institutes of Health
Awarded by US Department of Agriculture
Awarded by Bill & Melinda Gates Foundation
Awarded by Children's Discovery Institute
Awarded by Morphology and Biobank Cores of the Washington University School of Medicine Digestive Diseases Research Core Center
Awarded by National Institutes of Health-National Center for Advancing Translational Sciences
Awarded by National Health and Medical Research Council, Australia
Awarded by Medical Research Council
Awarded by NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES
Awarded by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
Awarded by NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
Funding Acknowledgements
This work was funded in part by National Institutes of Health [Grant U54 AI057160] to the Midwest Regional Center of Excellence for Biodefense and Emerging Infectious Disease Research, US Department of Agriculture [Grant 0202238], Bill & Melinda Gates Foundation [OPP1016839], Children's Discovery Institute (MD-FR-2013-292), the Morphology and Biobank Cores of the Washington University School of Medicine Digestive Diseases Research Core Center [P30DK052574], and National Institutes of Health-National Center for Advancing Translational Sciences [UL1 TR000448 sub award KL2 TR000450 to L.R.H.]. D.W. holds an Investigator in the Pathogenesis of Infectious Disease Award from the Burroughs Wellcome Fund. C.D.K. is supported by a Career Development Award fellowship from the National Health and Medical Research Council, Australia (607347).