Apoptotic Caspases Suppress mtDNA-Induced STING-Mediated Type I IFN Production
Michael J White, Kate McArthur, Donald Metcalf, Rachael M Lane, John C Cambier, Marco J Herold, Mark F van Delft, Sammy Bedoui, Guillaume Lessene, Matthew E Ritchie, David CS Huang, Benjamin T Kile
Cell | CELL PRESS | Published : 2014
Awarded by Australian National Health and Medical Research Council
Awarded by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
The authors thank J. Corbin and L. Di Rago for excellent technical assistance; K. Franks, E. Lanera, K. McGregor, S. Ross, K. Stoev, L. Wilkins, and E. Kryan for outstanding animal husbandry; S. Monard for expert flow cytometry assistance; T. Mak for Apaf1<SUP>+/-</SUP> mice; R. Flavell for Casp3<SUP>+/-</SUP> Casp7<SUP>+/-</SUP> mice; C. Thompson for Bak<SUP>+/</SUP> and Bax<SUP>+/</SUP> mice; P. Crack for Ifnar1<SUP>+/</SUP> mice; D. Fairlie and E. Lee for Bim variants; K. Aumann and C. De Nardo for manuscript assistance; and A. Strasser, J. Choi, S. Best, A. Rongvaux, and R. Flavell for insightful discussions. This work was supported by Project Grants (516725 and 575535), Program Grants (461219, 461221, and 1016647), Fellowships (D.C.S.H. and B.T.K.), and an Independent Research Institutes Infrastructure Support Scheme Grant (361646) from the Australian National Health and Medical Research Council; a scholarship from the Leukemia Foundation of Australia (M.J.W.), fellowships from the Cancer Council of Victoria (M.J.W. and D.M.); an Australian Postgraduate Award scholarship (K.M.); a fellowship from the Sylvia and Charles Viertel Foundation (B.T.K.); the Australian Cancer Research Fund; and a Victorian State Government Operational Infrastructure Support Grant.