Journal article

Differential factors associated with challenge-proven food allergy phenotypes in a population cohort of infants: a latent class analysis

RL Peters, KJ Allen, SC Dharmage, CJ Lodge, JJ Koplin, A-L Ponsonby, M Wake, AJ Lowe, MLK Tang, MC Matheson, LC Gurrin

Clinical & Experimental Allergy | WILEY | Published : 2015


BACKGROUND: Food allergy, eczema and wheeze are early manifestations of allergic disease and commonly co-occur in infancy although their interrelationship is not well understood. Data from population studies are essential to determine whether there are differential drivers of multi-allergy phenotypes. We aimed to define phenotypes and risk factors of allergic disease using latent class analysis (LCA). METHODS: The HealthNuts study is a prospective, population-based cohort of 5276 12-month-old infants in Melbourne, Australia. LCA was performed using the following baseline data collected at age 12 months: food sensitization (skin prick test ≥ 2 mm) and allergy (oral food challenge) to egg, pea..

View full abstract


Funding Acknowledgements

This work was supported by funding from the National Health & Medical Research Council (NHMRC) of Australia, Ilhan Food Allergy Foundation, AnaphylaxiStop, the Charles and Sylvia Viertel Medical Research Foundation, the Victorian Government's Operational Infrastructure Support Program and the NHMRC Centre for Food and Allergy Research. K.J.A. is a Viertel senior medical research fellow. R. P. is an Australian Postgraduate Award scholar. L. G., M. M., A. L., A.-L. P., J. K. and S. D. hold NHMRC awards.