Rational design and synthesis of an orally bioavailable peptide guided by NMR amide temperature coefficients
Conan K Wang, Susan E Northfield, Barbara Colless, Stephanie Chaousis, Ingrid Hamernig, Rink-Jan Lohman, Daniel S Nielsen, Christina I Schroeder, Spiros Liras, David A Price, David P Fairlie, David J Craik
Proceedings of the National Academy of Sciences | NATL ACAD SCIENCES | Published : 2014
Awarded by Australian Research Council Linkage Grant
Awarded by National Health and Medical Research Council (NHMRC) Early Career Research Fellowship
We thank Olivier Cheneval and Phillip Walsh for help with peptide synthesis. Caco-2 cells were kindly provided by Prof. Istvan Toth. This work was supported by Australian Research Council Linkage Grant LP110200213, co-funded by Pfizer and a Queensland Government Smart Futures Co-investment Grant. C.K.W. was supported by a National Health and Medical Research Council (NHMRC) Early Career Research Fellowship (546578). D.P.F. and D.J.C. are NHMRC Senior Principal Research Fellows (APP1027369, APP1026501).