Chronic intraocular pressure elevation impairs autoregulatory capacity in streptozotocin-induced diabetic rat retina
Vickie H Wong, James A Armitage, Zheng He, Flora Hui, Algis J Vingrys, Bang V Bui
OPHTHALMIC AND PHYSIOLOGICAL OPTICS | WILEY | Published : 2015
PURPOSE: To assess ocular blood flow responses to acute IOP stress following 4 weeks of chronic IOP elevation in streptozotocin (STZ)-induced diabetic and control rats. We hypothesise that chronic IOP elevation for 4 weeks will further impair blood flow regulation in STZ-induced diabetic rats eyes. METHODS: Two weeks following citrate buffer or STZ-injections chronic IOP elevation was induced in Long Evans rats via fortnightly intracameral injections of microspheres (15 μm) suspended in 5% polyethylene glycol. IOP was monitored daily. Electroretinography (ERG, -6.79-2.07 log cd s m(-2) ) was undertaken at Week 4 to compare photoreceptor (RmPIII ), ON-bipolar cell (Vmax ) and ganglion cell do..View full abstract
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Awarded by NHMRC
NHMRC project grants 566570 (BVB, AJV, JAA).