Journal article

Treatment Implications of Predominant Polarity and the Polarity Index: A Comprehensive Review

Andre F Carvalho, Joao Quevedo, Roger S McIntyre, Marcio G Soeiro-de-Souza, Konstantinos N Fountoulakis, Michael Berk, Thomas N Hyphantis, Eduard Vieta

International Journal of Neuropsychopharmacology | OXFORD UNIV PRESS | Published : 2015


BACKGROUND: Bipolar disorder (BD) is a serious and recurring condition that affects approximately 2.4% of the global population. About half of BD sufferers have an illness course characterized by either a manic or a depressive predominance. This predominant polarity in BD may be differentially associated with several clinical correlates. The concept of a polarity index (PI) has been recently proposed as an index of the antimanic versus antidepressive efficacy of various maintenance treatments for BD. Notwithstanding its potential clinical utility, predominant polarity was not included in the DSM-5 as a BD course specifier. METHODS: Here we searched computerized databases for original clinica..

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University of Melbourne Researchers