Treatment Implications of Predominant Polarity and the Polarity Index: A Comprehensive Review
Andre F Carvalho, Joao Quevedo, Roger S McIntyre, Marcio G Soeiro-de-Souza, Konstantinos N Fountoulakis, Michael Berk, Thomas N Hyphantis, Eduard Vieta
International Journal of Neuropsychopharmacology | OXFORD UNIV PRESS | Published : 2015
BACKGROUND: Bipolar disorder (BD) is a serious and recurring condition that affects approximately 2.4% of the global population. About half of BD sufferers have an illness course characterized by either a manic or a depressive predominance. This predominant polarity in BD may be differentially associated with several clinical correlates. The concept of a polarity index (PI) has been recently proposed as an index of the antimanic versus antidepressive efficacy of various maintenance treatments for BD. Notwithstanding its potential clinical utility, predominant polarity was not included in the DSM-5 as a BD course specifier. METHODS: Here we searched computerized databases for original clinica..View full abstract
Awarded by NHMRC
Dr Berk is supported by NHMRC Senior Principal Research Fellowship 1059660. Drs Carvalho and Quevedo are supported by research fellowships from Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq).