Journal article
Treatment implications of predominant polarity and the polarity index: a comprehensive review
AF Carvalho, J Quevedo, RS McIntyre, MG Soeiro-de-Souza, KN Fountoulakis, M Berk, TN Hyphantis, E Vieta
The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP) | Published : 2015
DOI: 10.1093/ijnp/pyu079
Abstract
© The Author 2015. Published by Oxford University Press on behalf of CINP. BACKGROUND: Bipolar disorder (BD) is a serious and recurring condition that affects approximately 2.4% of the global population. About half of BD sufferers have an illness course characterized by either a manic or a depressive predominance. This predominant polarity in BD may be differentially associated with several clinical correlates. The concept of a polarity index (PI) has been recently proposed as an index of the antimanic versus antidepressive efficacy of various maintenance treatments for BD. Notwithstanding its potential clinical utility, predominant polarity was not included in the DSM-5 as a BD course speci..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
Dr Berk is supported by NHMRC Senior Principal Research Fellowship 1059660. Drs Carvalho and Quevedo are supported by research fellowships from Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq).