Journal article
Influence of birth cohort on age of onset cluster analysis in bipolar I disorder
M Bauer, T Glenn, M Alda, OA Andreassen, E Angelopoulos, R Ardau, C Baethge, R Bauer, F Bellivier, RH Belmaker, M Berk, TD Bjella, L Bossini, Y Bersudsky, EYW Cheung, J Conell, M Del Zompo, S Dodd, B Etain, A Fagiolini Show all
European Psychiatry | Published : 2015
Abstract
Purpose: Two common approaches to identify subgroups of patients with bipolar disorder are clustering methodology (mixture analysis) based on the age of onset, and a birth cohort analysis. This study investigates if a birth cohort effect will influence the results of clustering on the age of onset, using a large, international database. Methods: The database includes 4037 patients with a diagnosis of bipolar I disorder, previously collected at 36 collection sites in 23 countries. Generalized estimating equations (GEE) were used to adjust the data for country median age, and in some models, birth cohort. Model-based clustering (mixture analysis) was then performed on the age of onset data usi..
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Awarded by Medical Research Council
Funding Acknowledgements
We thank the European College of Neuropsychopharmacology (ECNP) Network Initiative for supporting the European Network of Bipolar Research Expert Centres (ENBREC). This work was also funded in part by the following: Canadian Institutes of Health Research (MA, Grant number 64410); the Research Council of Norway (OAA Grant numbers 213837; 223273; 217776); South-East Norway Health Authority (OAA, Grant number 2013-123); a NHMRC Senior Principal Research Fellowship (M Berk, Grant number 1059660; INSERM (BE, Grant number C0829) and APHP (BE, Grant number AOR11096); the Spanish Government (AGP, Grant numbers PS09/02002 CIBER Network; EC10-333, PI10/01430, PI10/01746, PI11/01977, PI11/02708, 2011/1064, 11-BI-01, 1677-DJ-030, EC10-220); European Regional Development Funds (Grant numbers UE/2012/FI-STAR, UE/2013/TENDERMH, UE/2013/MASTERMIND), grants from Spanish Government (Grant numbers PI10/01430, PI10/01746, EC10-220, EC10-333, PI11/01977, 20111064, PI11/02708, PI12/02077, PI13/02252, PI13/00451), local grants from the Basque Government (Grant numbers 200911147, 2010111170, 2010112009, 2011111110, 2011111113); the Basque Foundation for Health Innovation and Research (Grant number BIO12/AL/002); the Spanish Clinical Research Network (Grant numbers CAI-BER; 1392-D-079) and the University of the Basque Country (Grant number IT679-13); Stanley Research Foundation (Grant number 03-RC-003); the Research Council of Norway (IM, Grant numbers ES488722, ES421716); the Regional Health Authority of South Eastern Norway (IM, Grants number 2011085, 2013088); DFG (AR, Grant numbers SFB TRR 58, B06, Z02); the DFG and Lander funds (AR, Grant number RTG1252/2); Medical Research Council of South Africa (DJS); Spanish Ministry of Economy and Competitiveness (EV, Grants number PI12/00912, PN 2008-2011); the Instituto de Salud Carlos III-Subdireccion General de Evaluacion y Fomento de la Investigacion (EV); Fondo Europeo de Desarrollo Regional Union Europea. Una manera de hacer Europa (EV); CIBERSAM (EV); the Comissionat per a Universitats i Recerca del DIUE de la Generalitat de Catalunya to the Bipolar Disorders Group (EV, Grant number 2009 SGR 1022), and the Department of Science and Technology INSPIRE scheme, Government of India (BV).