Fear extinction in 17 day old rats is dependent on metabotropic glutamate receptor 5 signaling

DE Ganella; P Thangaraju; AJ Lawrence; JH Kim

Journal article

Fear extinction in 17 day old rats is dependent on metabotropic glutamate receptor 5 signaling

DE Ganella, P Thangaraju, AJ Lawrence, JH Kim

Behavioural Brain Research | Published : 2016

DOI: 10.1016/j.bbr.2014.12.010

Abstract

We used pharmacological modulation of the mGlu5 receptor to investigate its role in the extinction of conditioned fear throughout development. In postnatal day (P) 17 rats, the positive allosteric modulator CDPPB facilitated, while the negative allosteric modulator MTEP impaired extinction. These drugs had no such effects on P24 or adult rats. These results establish a changing importance of mGlu5 in extinction of conditioned fear at distinct stages of development.

University of Melbourne Researchers

Andrew Lawrence Author

Grants

Funding Acknowledgements

This research was supported by a project grant (APP1022201) from the National Health and Medical Research Council (NHMRC) of Australia awarded to AJL and JHK, Australian Research Council Discovery Early Career Research Award Fellowship awarded to JHK, and NHMRC Principal Research Fellowship awarded to AJL. We acknowledge the Victorian Government's Operational Infrastructure Support Program. We would also like to thank Johnny Park and Simone Mizzi for manual scoring of freezing, and Florey Behavior Core Facility.