Fixed Expression of Single Influenza Virus-Specific TCR Chains Demonstrates the Capacity for TCR alpha- and beta-Chain Diversity in the Face of Peptide-MHC Class I Specificity
E Bridie Clemens, Peter C Doherty, Nicole L La Gruta, Stephen J Turner
The Journal of Immunology | AMER ASSOC IMMUNOLOGISTS | Published : 2015
The characteristics of the TCR repertoire expressed by epitope-specific CD8(+) T cells can be an important determinant of the quality of immune protection against virus infection. Most studies of epitope-specific TCR repertoires focus solely on an analysis of TCR β-chains, rather than the combined TCRαβ heterodimers that confer specificity. Hence, the importance of complementary α- and β-chain pairing in determining TCR specificity and T cell function is not well understood. Our earlier study of influenza-specific TCR repertoires in a C57BL/6J mouse model described a structural basis for preferred TCRαβ pairing that determined exquisite specificity for the D(b)PA224 epitope from influenza A ..View full abstract
Awarded by Australian National Health and Medical Research Council Grant
This work was supported by an Australian National Health and Medical Research Council Dora Lush Postgraduate Scholarship (to E.B.C.), Australian National Health and Medical Research Council Grant 5671222 (to S.J.T. and P.C.D.), an Australian Research Council Future Fellowship (to S.J.T.), and a Sylvia and Charles Viertal Charitable Foundation Senior Research Fellowship (to N.L.L.G.).