Journal article

Genetics of Microstructure of the Corpus Callosum in Older Adults

C Kanchibhotla, Karen A Mather, Anbupalam Thalamuthu, Lin Zhuang, Peter R Schofield, John BJ Kwok, David Ames, Margaret J Wright, Julian N Trollor, Wei Wen, Perminder S Sachdev

PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2014

Abstract

The current study sought to examine the relative influence of genetic and environmental factors on corpus callosum (CC) microstructure in a community sample of older adult twins. Analyses were undertaken in 284 healthy older twins (66% female; 79 MZ and 63 DZ pairs) from the Older Australian Twins Study. The average age of the sample was 69.82 (SD = 4.76) years. Brain imaging scans were collected and DTI measures were estimated for the whole CC as well as its five subregions. Parcellation of the CC was performed using Analyze. In addition, white matter lesion (WMLs) burden was estimated. Heritability and genetic correlation analyses were undertaken using the SOLAR software package. Age, sex,..

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University of Melbourne Researchers

Grants

Awarded by NHMRC/Australian Research Council


Awarded by NHMRC


Awarded by NHMRC Enabling Grant


Awarded by NHMRC Capacity Building Grant


Awarded by NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING


Funding Acknowledgements

OATS is supported by the NHMRC/Australian Research Council Strategic Award 401162 and NHMRC Project Grant 1045325. OATS was facilitated through access to the Australian Twin Registry, a national research resource supported by the NHMRC Enabling Grant 310667, administered by the University of Melbourne. Sri Chandana Kanchibhotla is supported by a scholarship from the Dementia Collaborative Research Centre (DCRC). Karen Mather is supported by an Alzheimer's Australia Dementia Research Foundation Postdoctoral Fellowship and the NHMRC Capacity Building Grant 568940. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.