Amyloid b-mediated Zn2 influx into dentate granule cells transiently induces a short-term cognitive deficit

Abstract

We examined an idea that short-term cognition is transiently affected by a state of confusion in Zn2+ transport system due to a local increase in amyloid-b (Ab) concentration. A single injection of Ab (25 pmol) into the dentate gyrus affected dentate gyrus long-term potentiation (LTP) 1 h after the injection, but not 4 h after the injection. Simultaneously, 1-h memory of object recognition was affected when the training was performed 1 h after the injection, but not 4 h after the injection. Abmediated impairments of LTP and memory were rescued in the presence of zinc chelators, suggesting that Zn2+ is involved in Ab action. When Ab was injected into the dentate gyrus, intracellular Zn2+ leve..