Journal article

The Impact of Injecting Networks on Hepatitis C Transmission and Treatment in People Who Inject Drugs

Margaret Hellard, David A Rolls, Rachel Sacks-Davis, Garry Robins, Philippa Pattison, Peter Higgs, Campbell Aitken, Emma McBryde

HEPATOLOGY | WILEY | Published : 2014


UNLABELLED: With the development of new highly efficacious direct-acting antiviral (DAA) treatments for hepatitis C virus (HCV), the concept of treatment as prevention is gaining credence. To date, the majority of mathematical models assume perfect mixing, with injectors having equal contact with all other injectors. This article explores how using a networks-based approach to treat people who inject drugs (PWID) with DAAs affects HCV prevalence. Using observational data, we parameterized an exponential random graph model containing 524 nodes. We simulated transmission of HCV through this network using a discrete time, stochastic transmission model. The effect of five treatment strategies on..

View full abstract