MC1R variants increased the risk of sporadic cutaneous melanoma in darker-pigmented Caucasians: A pooled-analysis from the M-SKIP project

E Pasquali; JC García-Borrón; MC Fargnoli; S Gandini; P Maisonneuve; V Bagnardi; C Specchia; F Liu; M Kayser; T Nijsten; E Nagore; R Kumar; J Hansson; PA Kanetsky; P Ghiorzo; T Debniak; W Branicki; NA Gruis; J Han; T Dwyer; L Blizzard; MT Landi; G Palmieri; G Ribas; A Stratigos; ML Council; P Autier; J Little; J Newton-Bishop; F Sera; S Raimondi; S Caini; A Hofman; AG Uitterlinden; D Scherer; V Hoiom; L Pastorino; J Cochrane; R Fernandez-De-Misa; N Morling; P Johansen; R Pfeiffer; K Kypreou; A Bowcock; L Cornelius; T Motokawa; S Anno; P Helsing; PA Andresen; TH Wong

Journal article

MC1R variants increased the risk of sporadic cutaneous melanoma in darker-pigmented Caucasians: A pooled-analysis from the M-SKIP project

E Pasquali, JC García-Borrón, MC Fargnoli, S Gandini, P Maisonneuve, V Bagnardi, C Specchia, F Liu, M Kayser, T Nijsten, E Nagore, R Kumar, J Hansson, PA Kanetsky, P Ghiorzo, T Debniak, W Branicki, NA Gruis, J Han, T Dwyer Show all

International Journal of Cancer | Published : 2015

DOI: 10.1002/ijc.29018

Abstract

The MC1R gene is a key regulator of skin pigmentation. We aimed to evaluate the association between MC1R variants and the risk of sporadic cutaneous melanoma (CM) within the M-SKIP project, an international pooled-analysis on MC1R, skin cancer and phenotypic characteristics. Data included 5,160 cases and 12,119 controls from 17 studies. We calculated a summary odds ratio (SOR) for the association of each of the nine most studied MC1R variants and of variants combined with CM by using random-effects models. Stratified analysis by phenotypic characteristics were also performed. Melanoma risk increased with presence of any of the main MC1R variants: the SOR for each variant ranged from 1.47 (95..

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