Journal article

Development of a safe dexamethasone-eluting electrode array for cochlear implantation.

Dimitra Stathopoulos, Scott Chambers, Ya Lang Enke, Godofredo Timbol, Frank Risi, Christopher Miller, Robert Cowan, Carrie Newbold

Cochlear Implants Int | Published : 2014


OBJECTIVES: Cochlear implantation can result in trauma leading to increased tissue response and loss of residual hearing. A single intratympanic application of the corticosteroid dexamethasone is sometimes used clinically during surgery to combat the potential effect of trauma on residual hearing. This project looked at the safety and efficacy of dexamethasone eluted from an intracochlear array in vivo. METHODS: Three trials were conducted using normal hearing adult guinea pigs implanted with successive iterations of dexamethasone-eluting (DX1, DX2, and DX3) or non-eluting (control) intracochlear electrode arrays. The experimental period for each animal was 90 days during which hearing tests..

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