Evidence linking FMR1 mRNA and attentional demands of stepping and postural control in women with the premutation
Darren R Hocking, Claudine M Kraan, David E Godler, Quang M Bui, Xin Li, John L Bradshaw, Nellie Georgiou-Karistianis, Sylvia A Metcalfe, Alison D Archibald, Erin Turbitt, Joanne Fielding, Julian Trollor, Jonathan Cohen, Kim M Cornish
NEUROBIOLOGY OF AGING | ELSEVIER SCIENCE INC | Published : 2015
Recent studies in young adult females with the fragile X mental retardation 1 (FMR1) gene premutation (PM) have shown subtle but significant impairments in executive control and postural stability. Less is known about the influence of age and FMR1 gene expression on executive control and postural stability in females with the PM. Here, we examined the attentional demands of reactive stepping using a well-validated measure of choice stepping reaction time under dual-task interference. We explored the interrelationships between step initiation times during a concurrent verbal fluency task and specific impairments in executive control previously reported in females with the PM. Our results show..View full abstract
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Awarded by Australian Research Council Discovery grant
Awarded by NHMRC project grant
This work was supported by an Australian Research Council Discovery grant (DP110103346) to Kim Cornish, Nellie Georgiou-Karistianis, Sylvia A. Metcalfe, Julian Trollor, Joanne Fielding and John L. Bradshaw, and a Monash University Research Fellowship to Darren R. Hocking. David E. Godler and Xin Li were supported by NHMRC project grant (No 104299 to David E. Godler), the Victorian Government's Operational Infrastructure Support Program and in part by Murdoch Childrens Research Institute, Genetics Theme funding. Sylvia A. Metcalfe was supported by the University of Melbourne. Sylvia A. Metcalfe, Erin Turbitt, and Alison D. Archibald were supported by the Murdoch Childrens Research Institute and the Victorian Government's Operational Infrastructure Support Program. The authors express their thanks to the Fragile X Association of Australia and Fragile X Alliance for their support in recruitment. They also thank Jonathan Whitty from Healthscope Pathology for assistance on the molecular procedures and Anna Atkinson for helping with the data collection. In addition, they acknowledge the assistance from Neuroscience Research Australia (Prof. Stephen Lord and Dr Stuart Smith) on extraction of choice stepping reaction time data. Finally, they are indebted to all the individuals who participated in this research. Darren Hocking, Claudine Kraan, and Kim Cornish (first, second, and last author) conceptualized and designed the study, provided intellectual input into the interpretation of the data and co-wrote the first draft of the article. David Godler and Xin Li (third and fifth authors) conducted the molecular analyses, provided intellectual input into interpretation, as well as inputs into drafts of the article. Minh Bui (fourth author) conducted the statistical analyses as well as inputs into the final drafts of the article. John Bradshaw (sixth author) provided intellectual input into the design of the study and the drafting of the article. Nellie Georgiou-Karistianis (seventh author) provided intellectual input into drafts of the article. Sylvia Metcalfe and Alison Archibald (eighth and ninth authors) assisted with recruitment, facilitated genetic testing of participants, and contributed to the article. Erin Turbitt (10th author) conducted the processing of blood samples for DNA analysis and preparing peripheral blood leucocytes for messenger RNA analysis, and contributed to editing the final draft of the article. Joanne Fielding (11th author) provided intellectual input into the drafting of the article. Julian Troller (12th author) assisted the design of the study, critical review and revision of the article, and interpretation of results. Jonathan Cohen (13th author) assisted with recruitment and contributed to drafts of the article.