Journal article
IGFBP-2: The dark horse in metabolism and cancer
VC Russo, WJ Azar, SW Yau, MA Sabin, GA Werther
Cytokine and Growth Factor Reviews | Published : 2015
Abstract
The ubiquitous nature of the IGF system, expressed early in embryonic development throughout postnatal and adult life, indicates a key role for this system in human biology. Studies of transgenic mice over-expressing components of the IGF system or mice with disruptions of the same genes have clearly shown that the IGF system plays an important role in vivo. The activity of the IGF ligands, elicited via their receptors and transduced by various intracellular signal pathways, is modulated by the IGFBPs. Among all the IGFBPs, IGFBP-2 has been implicated in the regulation of IGF activity in the nervous system, peripheral tissue and organs. Besides binding to IGFs in the circulation, these IGF-r..
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Awarded by Murdoch Children's Research Institute
Funding Acknowledgements
This work was supported by the National Health and Medical Research Council (NHMRC) of Australia (Project Grant, #1008062) awarded to GAW and VCR. MAS is supported through a National Health and Medical Research Council Professional Training Fellowship (APP1012201). SWY is a recipient of an Australian Postgraduate Award scholarship. We also wish to acknowledge the generous support from the Murdoch Childrens Research Institute and the Royal Children's Hospital Foundation to GAW, MAS and VCR. We also thank the Victorian Government Operational Infrastructure Support Program.