Journal article
Independent confirmation of juvenile idiopathic arthritis genetic risk loci previously identified by immunochip array analysis
RC Chiaroni-Clarke, JE Munro, RA Chavez, A Pezic, RC Allen, JD Akikusa, SE Piper, R Saffery, AL Ponsonby, JA Ellis
Pediatric Rheumatology | Published : 2014
Open access
Abstract
Background: Our understanding of the genetic factors underlying juvenile idiopathic arthritis (JIA) is growing, but remains incomplete. Recently, a number of novel genetic loci were reported to be associated with JIA at (or near) genome-wide significance in a large case-control discovery sample using the Immunochip genotyping array. However, independent replication of findings has yet to be performed. We therefore attempted to replicate these newly identified loci in the Australian CLARITY JIA case-control sample. Findings: Genotyping was successfully performed on a total of 404 JIA cases (mean age 6.4 years, 68% female) and 676 healthy child controls (mean age 7.1 years, 42% female) across ..
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Awarded by Australian Research Council
Funding Acknowledgements
We thank the participants and their families for their generous donation of information and biospecimens to this study, along with the research staff who recruited them. We acknowledge funding from the National Health and Medical Research Council of Australia (NHMRC, #APP1026349), along with a number of other philanthropic organisations including Arthritis Australia and the Rebecca Cooper Foundation. The work was supported by the Victorian State Government Operational Infrastructure Program. JAE is supported by an Australian Research Council Future Fellowship. ALP and RS are supported by National Health and Medical Research Council (Australia) Senior Research Fellowships.