Early Respiratory Infection Is Associated with Reduced Spirometry in Children with Cystic Fibrosis
Kathryn A Ramsey, Sarath Ranganathan, Judy Park, Billy Skoric, Anne-Marie Adams, Shannon J Simpson, Roy M Robins-Browne, Peter J Franklin, Nick H de Klerk, Peter D Sly, Steve M Stick, Graham L Hall
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE | AMER THORACIC SOC | Published : 2014
RATIONALE: Pulmonary inflammation, infection, and structural lung disease occur early in life in children with cystic fibrosis. OBJECTIVES: We hypothesized that the presence of these markers of cystic fibrosis lung disease in the first 2 years of life would be associated with reduced lung function in childhood. METHODS: Lung function (forced expiratory volume in the first three-quarters of a second [FEV0.75], FVC) was assessed in individuals with cystic fibrosis diagnosed after newborn screening and healthy subjects during infancy (0-2 yr) and again at early school age (4-8 yr). Individuals with cystic fibrosis underwent annual bronchoalveolar lavage fluid examination, and chest computed tom..View full abstract
Awarded by Cystic Fibrosis Foundation Therapeutics
Awarded by National Health and Medical Research Council of Australia (NHMRC) (AREST CF program)
Awarded by National Health and Medical Research Council of Australia (Centre of Research Excellence) (AREST CF program)
Supported by Cystic Fibrosis Foundation Therapeutics (SLY04A0, STICK09A0) and the National Health and Medical Research Council of Australia (NHMRC; APP513730 and Centre of Research Excellence #1000896) (AREST CF program). G.L.H. is an NHMRC Fellow (APP1025550).