Journal article

pH-Responsive Capsules Engineered from Metal-Phenolic Networks for Anticancer Drug Delivery

Yuan Ping, Junling Guo, Hirotaka Ejima, Xi Chen, Joseph J Richardson, Huanli Sun, Frank Caruso

SMALL | WILEY-V C H VERLAG GMBH | Published : 2015

Abstract

A new class of pH-responsive capsules based on metal-phenolic networks (MPNs) for anticancer drug loading, delivery and release is reported. The fabrication of drug-loaded MPN capsules, which is based on the formation of coordination complexes between natural polyphenols and metal ions over a drug-coated template, represents a rapid strategy to engineer robust and versatile drug delivery carriers.

Grants

Awarded by Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology


Awarded by Australian Research Council


Funding Acknowledgements

This research was conducted and funded by the Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology (project number CE140100036) and by the Australian Research Council under the Australian Laureate Fellowship (FL120100030) and Discovery Project (DP0877360) schemes. The authors acknowledge Benjamin Hibbs (Advanced Fluorescence Imaging Platform, The University of Melbourne) for assistance with super-resolution microscopy and Qiong Dai for help with flow cytometry analysis. The authors acknowledge Martin van Koeverden for helpful discussions.