Journal article
Soluble ligands and their receptors in human embryo development and implantation
GA Thouas, F Dominguez, MP Green, F Vilella, C Simon, DK Gardner
Endocrine Reviews | Published : 2015
DOI: 10.1210/er.2014-1046
Abstract
Extensive evidence suggests that soluble ligands and their receptors mediate human preimplantation embryo development and implantation. Progress in this complex area has been ongoing since the 1980s, with an ever-increasing list of candidates. This article specifically reviews evidence of soluble ligands and their receptors in the human preimplantation stage embryo and female reproductive tract. The focus will be on candidates produced by the human preimplantation embryo and those eliciting developmental responses in vitro, as well as endometrial factors related to implantation and receptivity. Pathways to clinical translation, including innovative diagnostics and other technologies, are als..
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Awarded by Spanish Ministry for Economy and Competitiveness (Miguel Servet Grant)
Awarded by Spanish Ministry for Economy and Competitiveness via Instituto de Salud Carlos III (Miguel Servet Grant)
Funding Acknowledgements
G.A.T. was funded by a grant from Vitrolife AB. F.D. is funded by the Spanish Ministry for Economy and Competitiveness (Miguel Servet Grant CP13/00075), and F.V. is funded by the same, via the Instituto de Salud Carlos III (Miguel Servet Grant CP13/00038). M.P.G. receives lectureship support from Merck Serono. D.K.G. receives fees and grant support from Vitrolife AB. C.S. is a shareholder of Instituto Valenciano de Infertilidad (IVI) and Igenomix (previously IVIOMICS) and has received fees and grant support from Ferring Pharmaceuticals, Merck Serono, Merck Sharpe & Dohme, OvaScience LLC, Pantharei Bioscience, and Schering AG.