Lack of durable disease control with chemotherapy for mycosis fungoides and Sézary syndrome: A comparative study of systemic therapy

Abstract

Numerous systemic treatment options exist for patients with mycosis fungoides(MF) and Sézary syndrome (SS), but no large comparative studies are published. To study the efficacy of treatments, are trospective analysis of our cutaneous lymphoma database was undertaken, with 198 MF/SS patients undergoing systemic therapies. The primary end point was time to next treatment (TTNT). Patients with advanced-stage disease made up 53%. The median follow-up time from diagnosis for all alive patients was 4.9 years (range 0.3-39.6), with a median survival of 11.4 years. Patients received a median of 3 lines of therapy(range1-13), resulting in 709 treatment episodes. Twenty-eight treatment modalities wer..