Higher Serum Undercarboxylated Osteocalcin and Other Bone Turnover Markers Are Associated With Reduced Diabetes Risk and Lower Estradiol Concentrations in Older Men
Bu B Yeap, Helman Alfonso, SA Paul Chubb, Richard Gauci, Elizabeth Byrnes, John P Beilby, Peter R Ebeling, David J Handelsman, Carolyn A Allan, Mathis Grossmann, Paul E Norman, Leon Flicker
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM | ENDOCRINE SOC | Published : 2015
CONTEXT: In mice, undercarboxylated osteocalcin (ucOC) modulates insulin secretion and sensitivity and increases testosterone (T) secretion from Leydig cells, but human data are lacking. We hypothesized that ucOC is associated with diabetes risk and modulates sex hormone concentrations in older men, distinct from other bone turnover markers. PARTICIPANTS: PARTICIPANTS were community-dwelling men aged 70 to 89 years resident in Perth, Western Australia. MAIN OUTCOME MEASURES: Serum total osteocalcin (TOC), N-terminal propeptide of type I collagen (P1NP), and collagen type I C-terminal cross-linked telopeptide (CTX) were measured by immunoassay, and ucOC by hydroxyapatite binding. Plasma total..View full abstract
Awarded by National Heart Foundation of Australia
Awarded by National Health and Medical Research Council of Australia
B.B.Y. is recipient of a Clinical Investigator Award from the Sylvia and Charles Viertel Charitable Foundation, New South Wales, Australia. This study was supported by Grant-in-Aid G11P 5662 from the National Heart Foundation of Australia. The Health In Men Study was funded by Project Grants 279408, 379600, 403963, 513823, 634492, 1045710, and 1060557 from the National Health and Medical Research Council of Australia. The funding sources had no involvement in the planning, analysis, and writing of the manuscript.