Journal article
Genetic dissection of acute anterior uveitis reveals similarities and differences in associations observed with ankylosing spondylitis
PC Robinson, TAM Claushuis, A Cortes, TM Martin, DM Evans, P Leo, P Mukhopadhyay, LA Bradbury, K Cremin, J Harris, WP Maksymowych, RD Inman, P Rahman, N Haroon, L Gensler, JE Powell, IE Van Der Horst-Bruinsma, AW Hewitt, JE Craig, LL Lim Show all
Arthritis and Rheumatology | Published : 2015
DOI: 10.1002/art.38873
Abstract
Conclusion These findings of both novel AAU-specific associations and associations shared with AS demonstrate overlapping but also distinct genetic susceptibility loci for AAU and AS. The associations in IL10 and IL18R1 are shared with inflammatory bowel disease, suggesting common etiologic pathways.Objective To use high-density genotyping to investigate the genetic associations of acute anterior uveitis (AAU) in patients with and those without ankylosing spondylitis (AS)Methods We genotyped samples from 1,711 patients with AAU (either primary or combined with AS), 2,339 AS patients without AAU, and 10,000 control subjects on an Illumina Immunochip Infinium microarray. We also used data for ..
View full abstractGrants
Awarded by National Institute of Arthritis and Musculoskeletal and Skin Diseases
Funding Acknowledgements
Supported by NIH/National Center for Advancing Translational Science (NCATS) UCLA CTSI grant UL1TR000124 and NIH grant P01-AR-052915 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases. Dr. Robinson's work was supported by the National Health and Medical Research Council of Australia and the University of Queensland Diamantina Institute. Dr. Claushuis' work was supported by a fellowship from Saal van Zwanenbergstichting, The Netherlands. Dr. Martin's work was supported by the National Eye Institute (grant R01-EY013139). Dr. Brown's work was supported by the Australian National Health and Medical Research Council (Senior Principal Research Fellowship). The Spondyloarthritis Research Consortium of Canada was funded by The Arthritis Society, Canada. The Australo-Anglo-American Spondylitis Consortium study was funded by the NIH (National Institute of Arthritis and Musculoskeletal and Skin Diseases grants P01-052915 and R01-AR-046208). The Casey Eye Institute is supported by Research to Prevent Blindness, New York, New York. Funding support for the recruitment of cases was provided by Arthritis Research UK (grants 19536 and 18797), The National Ankylosing Spondylitis Society, and NIHR Thames Valley Comprehensive Local Research Network.Dr. Inman has received consulting fees, speaking fees, and/or honoraria from AbbVie, Amgen, Janssen Pharmaceuticals, UCB, Celgene, and Pfizer (less than $10,000 each). Dr. Rahman has received consulting fees from AbbVie, Amgen, Janssen Pharmaceuticals, Novartis, and Roche (less than $10,000 each). Dr. Haroon has received consulting fees, speaking fees, and/or honoraria from AbbVie, Amgen, Janssen Pharmaceuticals, Celgene, and UCB (less than $10,000 each). Dr. Weisman has received consulting fees from UCB (less than $10,000).