Journal article

Application of genetic markers to the identification of recrudescent Plasmodium falciparum infections on the northwestern border of Thailand

A Brockman, REL Paul, TJC Anderson, I Hackford, L Phaiphun, S Looareesuwan, F Nosten, KP Day

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE | AMER SOC TROP MED & HYGIENE | Published : 1999

Abstract

Parasite genotyping by the polymerase chain reaction was used to distinguish recrudescent from newly acquired Plasmodium falciparum infections in a Karen population resident on the northwestern border of Thailand where malaria transmission is low (one infection/person/year). Plasmodium falciparum infections were genotyped for allelic variation in three polymorphic antigen loci, merozoite surface proteins-1 and -2 (MSP-1 and -2) and glutamaterich protein (GLURP), before and after antimalarial drug treatment. Population genotype frequencies were measured to provide the baseline information to calculate the probability of a new infection with a different or the same genotype to the initial pret..

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University of Melbourne Researchers