Journal article
Insulin and BMI as predictors of adult type 2 diabetes mellitus
MA Sabin, CG Magnussen, M Juonala, JPH Shield, M Kähönen, T Lehtimäki, T Rönnemaa, J Koskinen, BM Loo, M Knip, N Hutri-Kähönen, JSA Viikari, T Dwyer, OT Raitakari
Pediatrics | Published : 2015
Abstract
BACKGROUND AND OBJECTIVES: Fasting insulin concentrations are increasingly being used as a surrogate for insulin resistance and risk for type 2 diabetes (T2DM), although associations with adult outcomes are unclear. Our objective was to determine whether fasting insulin concentrations in childhood associate with later T2DM.METHODS: Fasting insulin values were available from 2478 participants in the longitudinal Cardiovascular Risk in Young Finns Study at baseline age 3 to 18 years, along with data on adult T2DM (N = 84, mean age = 39.6 years).RESULTS: Among 3- to 6-year-olds, a 1-SD increase in fasting insulin was associated with a relative risk (RR) of 2.04 (95% confidence interval [CI], 1...
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Funding Acknowledgements
The Young Finns Study was financially supported by the Academy of Finland, grants 134309 (Eye), 126925, 121584, 124282, 129378 (Salve), 117787 (Gendi), and 41071 (Skidi); the Social Insurance Institution of Finland; Kuopio, Tampere and Turku University Hospital Medical Funds (9N035); Juho Vainio Foundation; Paavo Nurmi Foundation; Finnish Foundation of Cardiovascular Research and Finnish Cultural Foundation; Tampere Tuberculosis Foundation; and Emil Aaltonen Foundation. Authors from the Murdoch Childrens Research Institute are supported by the Victorian Government's Operational Infrastructure Support Program. M.A.S. is supported through a National Health and Medical Research Council Health Professional Training Fellowship (APP1012201). C.G.M. is supported through a National Health and Medical Research Council Early Career Fellowship (APP1037559).