Journal article

Epitope-specific CD4( ), but not CD8( ), T-cell responses induced by recombinant influenza A viruses protect against Mycobacterium tuberculosis infection

Manuela Florido, Roman Pillay, Caitlin M Gillis, Yingju Xia, Stephen J Turner, James A Triccas, John Stambas, Warwick J Britton

EUROPEAN JOURNAL OF IMMUNOLOGY | WILEY | Published : 2015

Abstract

Tuberculosis remains a global health problem, in part due to failure of the currently available vaccine, BCG, to protect adults against pulmonary forms of the disease. We explored the impact of pulmonary delivery of recombinant influenza A viruses (rIAVs) on the induction of Mycobacterium tuberculosis (M. tuberculosis)-specific CD4(+) and CD8(+) T-cell responses and the resultant protection against M. tuberculosis infection in C57BL/6 mice. Intranasal infection with rIAVs expressing a CD4(+) T-cell epitope from the Ag85B protein (PR8.p25) or CD8(+) T-cell epitope from the TB10.4 protein (PR8.TB10.4) generated strong T-cell responses to the M. tuberculosis-specific epitopes in the lung that p..

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