BCG-associated heterologous immunity, a historical perspective: intervention studies in animal models of infectious diseases
Bridget Freyne, Arnaud Marchant, Nigel Curtis
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE | OXFORD UNIV PRESS | Published : 2015
The WHO Special Advisory Group of Experts (SAGE) review of the available epidemiological and trial evidence in humans concluded that bacillus Calmette-Guérin (BCG) vaccination leads to beneficial heterologous ('non-specific') effects, specifically on all-cause mortality. Randomized controlled trials showing this beneficial effect suggest improved survival is the result of enhanced protection against infection. This paper reviews the available evidence for the attenuating effects of BCG vaccine on experimental infections in animal models, including protection from bacteria, viruses, parasites and fungi. The reviewed studies suggest that BCG activates multiple immune pathways and that the basi..View full abstract
BF is a PhD student at The University of Melbourne and funded by scholarships from the University of Melbourne, the Nossal Institute of Global Health and the European Society for Paediatric Infectious Diseases. AM is a senior research associate of the Fonds de la Recherche Scientifique (F.R.S.-FNRS), Belgium.