Journal article

Modulation of antigen presentation by intracellular trafficking

Justine D Mintern, Christophe Macri, Jose A Villadangos

CURRENT OPINION IN IMMUNOLOGY | CURRENT BIOLOGY LTD | Published : 2015

Abstract

Processing and loading of antigen into major histocompatibility complex molecules (MHC) occurs in specific intracellular compartments. Accessing MHC loading compartments requires trafficking via specific pathways, some of which have yet to be fully characterized. For MHC I, cross-presentation involves antigen trafficking to a specialised compartment. We review the features of this compartment and how it is accessed by different mechanisms of antigen capture and internalization. We also summarize advances in understanding how antigen efficiently accesses the MHC II loading compartment, with particular focus on the role of autophagy. Understanding the mechanisms that control how antigen is tra..

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