Modulation of antigen presentation by intracellular trafficking
Justine D Mintern, Christophe Macri, Jose A Villadangos
CURRENT OPINION IN IMMUNOLOGY | CURRENT BIOLOGY LTD | Published : 2015
Processing and loading of antigen into major histocompatibility complex molecules (MHC) occurs in specific intracellular compartments. Accessing MHC loading compartments requires trafficking via specific pathways, some of which have yet to be fully characterized. For MHC I, cross-presentation involves antigen trafficking to a specialised compartment. We review the features of this compartment and how it is accessed by different mechanisms of antigen capture and internalization. We also summarize advances in understanding how antigen efficiently accesses the MHC II loading compartment, with particular focus on the role of autophagy. Understanding the mechanisms that control how antigen is tra..View full abstract
JDM and JAV are supported by the National Health and Medical Research Council of Australia. CM is the recipient of a fellowship from the Fondation pour la Recherche Medicale (France).