Journal article
Administration of a probiotic with peanut oral immunotherapy: A randomized trial
MLK Tang, AL Ponsonby, F Orsini, D Tey, M Robinson, EL Su, P Licciardi, W Burks, S Donath
Journal of Allergy and Clinical Immunology | Published : 2015
Abstract
Background Coadministration of a bacterial adjuvant with oral immunotherapy (OIT) has been suggested as a potential treatment for food allergy.Objective To evaluate a combined therapy comprising a probiotic together with peanut OIT.Methods We performed a double-blind, placebo-controlled randomized trial of the probiotic Lactobacillus rhamnosus CGMCC 1.3724 and peanut OIT (probiotic and peanut oral immunotherapy [PPOIT]) in children (1-10 years) with peanut allergy. The primary outcome was induction of sustained unresponsiveness 2 to 5 weeks after discontinuation of treatment (referred to as possible sustained unresponsiveness). Secondary outcomes were desensitization, peanut skin prick test,..
View full abstractGrants
Awarded by Cass Foundation
Funding Acknowledgements
Supported by the Food Allergy and Anaphylaxis Network (FAAN), the Murdoch Childrens Research Institute, Perpetual Philanthropy (grant ID 493), the CASS Foundation, the Financial Markets Foundation for Children and the National Health and Medical Research Council Australia (NHMRC project grant no. 1029690). Nestle Health Science were provided a copy of the final draft before submission (as required by a Material Transfer Agreement).