Journal article

A genome-wide association study of marginal zone lymphoma shows association to the HLA region

Joseph Vijai, Zhaoming Wang, Sonja I Berndt, Christine F Skibola, Susan L Slager, Silvia de Sanjose, Mads Melbye, Bengt Glimelius, Paige M Bracci, Lucia Conde, Brenda M Birmann, Sophia S Wang, Angela R Brooks-Wilson, Qing Lan, Paul IW de Bakker, Roel CH Vermeulen, Carol Portlock, Stephen M Ansell, Brian K Link, Jacques Riby Show all

Nature Communications | NATURE PUBLISHING GROUP | Published : 2015

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Awarded by U.S. Public Health Service contracts


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Awarded by EpiLymph-European Commission


Awarded by Spanish Ministry of Health


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Awarded by Agencia de Gestiod'AjutsUniversitarisi de Recerca-Generalitat de Catalunya


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Awarded by Jose Carreras Leukemia Foundation


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Awarded by RECAMO


Awarded by National Institutes of Health


Awarded by Specialized Programs of Research Excellence (SPORE) in Human Cancer


Awarded by Molecular Epidemiology of Non-Hodgkin Lymphoma Survival


Awarded by Italian Ministry for Education, University and Research


Awarded by Italian Association for Cancer Research (AIRC)


Awarded by Regional Administration of Sardinia


Awarded by Fondazione Banco di Sardegna


Awarded by National Center for Advancing Translational Science


Awarded by Australian NHMRC


Awarded by Geoffrey Beene Cancer Research Grant, Lymphoma Foundation


Awarded by Barbara K. Lipman Lymphoma Research Fund


Awarded by Robert and Kate Niehaus Clinical Cancer Genetics Research Initiative


Awarded by Public Health Service


Awarded by Australian National Health and Medical Research Council


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Awarded by National Cancer Institute's Surveillance, Epidemiology and End Results Program


Awarded by Centers for Disease Control and Prevention's National Program of Cancer Registries


Awarded by National Heart, Lung and Blood Institute, National Institutes of Health, U.S. Department of Health and Human Services


Awarded by National Cancer Institute


Funding Acknowledgements

Support for individual studies: ATBC-Intramural Research Program of the National Institutes of Health, NCI, Division of Cancer Epidemiology and Genetics. U.S. Public Health Service contracts (N01-CN-45165, N01-RC-45035, N01-RC-37004); BCCA (J.J.S., A.R.B.-W.)-Canadian Institutes for Health Research (CIHR). Canadian Cancer Society, Michael Smith Foundation for Health Research; CPS-II (L.F.T.)-The American Cancer Society funds the creation, maintenance and updating of the CPS-II cohort. We thank the CPS-II participants and the Study Management Group for their invaluable contributions to this research. We would also like to acknowledge the contribution to this study from the central cancer registries supported through the Centers for Disease Control and Prevention National Program of Cancer Registries and cancer registries supported by the National Cancer Institute Surveillance Epidemiology and End Results program; ELCCS (E.R.)-Leukaemia & Lymphoma Research; ENGELA (J.C.)-Fondation ARC pour la Recherche sur le Cancer. Fondation de France. French Agency for Food, Environmental and Occupational Health & Safety (ANSES), the French National Cancer Institute (INCa); EPIC (E.R.)-Coordinated Action (Contract #006438, SP23-CT-2005-006438). HuGeF (Human Genetics Foundation), Torino, Italy; EpiLymph-European Commission (grant references QLK4-CT-2000-00422 and FOOD-CT-2006-023103); the Spanish Ministry of Health (grant references CIBERESP, PI11/01810, RCESP C03/09, RTICESP C03/10 and RTIC RD06/0020/0095), the Marato de TV3 Foundation (grant reference 051210), the Agencia de Gestiod'AjutsUniversitarisi de Recerca-Generalitat de Catalunya (grant reference 2009SGR1465) who had no role in the data collection, analysis or interpretation of the results; the NIH (contract NO1-CO-12400); the Compagnia di San Paolo-Programma Oncologia; the Federal Office for Radiation Protection grants StSch4261 and StSch4420, the Jose Carreras Leukemia Foundation grant DJCLS-R12/23, the German Federal Ministry for Education and Research (BMBF-01-EO-1303); the Health Research Board, Ireland and Cancer Research Ireland; Czech Republic supported by MH CZ-DRO (MMCI, 00209805) and RECAMO, CZ.1.05/2.1.00/03.0101; Fondation de France and Association de Recherche Contre le Cancer; HPFS (Walter C. Willet)-The HPFS was supported in part by National Institutes of Health grants CA167552, CA149445, CA098122, CA098566 (K.A.B.) and K07 CA115687 (B.M.B.). We would like to thank the participants and staff of the Health Professionals Follow-up Study for their valuable contributions as well as the following state cancer registries for their help: AL, AZ, AR, CA, CO, CT, DE, FL, GA, ID, IL, IN, IA, KY, LA, ME, MD, MA, MI, NE, NH, NJ, NY, NC, ND, OH, OK, OR, PA, RI, SC, TN, TX, VA, WA, WY. In addition, this study was approved by the Connecticut Department of Public Health (DPH) Human Investigations Committee. Certain data used in this publication were obtained from the DPH. The authors assume full responsibility for analyses and interpretation of these data; Iowa-Mayo SPORE (G.J.W., J.R.C., T.E.W.)-National Institutes of Health (CA97274). Specialized Programs of Research Excellence (SPORE) in Human Cancer (P50 CA97274). Molecular Epidemiology of Non-Hodgkin Lymphoma Survival (R01 CA129539). Henry J. Predolin Foundation; Italian GxE (P.C.)-Italian Ministry for Education, University and Research (PRIN 2007 prot.2007WEJLZB, PRIN 2009 prot. 20092ZELR2); the Italian Association for Cancer Research (AIRC, Investigator Grant 11855). (M.G.E.)-Regional Law N.7, 2007: 'Basic research' (Progetti di ricerca fondamentale o di base) by the Regional Administration of Sardinia (CRP-59812/2012), Fondazione Banco di Sardegna 20102012; Mayo Clinic Case-Control (J.R.C.)-National Institutes of Health (R01 CA92153). National Center for Advancing Translational Science (UL1 TR000135); MCCS (G.G.G., G.S.)-The Melbourne Collaborative Cohort Study recruitment was funded by VicHealth and Cancer Council Victoria. The MCCS was further supported by Australian NHMRC grants 209057, 251553 and 504711 and by infrastructure provided by Cancer Council Victoria; MD Anderson (X.W.)-Institutional support to the Center for Translational and Public Health Genomics; MSKCC (K.O.)-Geoffrey Beene Cancer Research Grant, Lymphoma Foundation (LF5541). Barbara K. Lipman Lymphoma Research Fund (74419). Robert and Kate Niehaus Clinical Cancer Genetics Research Initiative (57470), U01 HG007033; NCI-SEER-Intramural Research Program of the National Cancer Institute, National Institutes of Health, and Public Health Service (N01-PC-65064, N01-PC-67008, N01-PC-67009, N01-PC-67010, N02-PC-71105); NHS (Meir J. Stampfer)-The NHS was supported in part by National Institutes of Health grants CA87969, CA49449, CA149445, CA098122, CA098566 (K.A.B.), and K07 CA115687 (B.M.B.). We would like to thank the participants and staff of the Nurses' Health Study for their valuable contributions as well as the following state cancer registries for their help: AL, AZ, AR, CA, CO, CT, DE, FL, GA, ID, IL, IN, IA, KY, LA, ME, MD, MA, MI, NE, NH, NJ, NY, NC, ND, OH, OK, OR, PA, RI, SC, TN, TX, VA, WA, WY. In addition, this study was approved by the Connecticut Department of Public Health (DPH) Human Investigations Committee. Certain data used in this publication were obtained from the DPH. The authors assume full responsibility for analyses and interpretation of these data; NSW (C.M. Vajdic)-was supported by grants from the Australian National Health and Medical Research Council (ID990920), the Cancer Council NSW, and the University of Sydney Faculty of Medicine; NYU-WHS-National Cancer Institute (R01 CA098661, P30 CA016087). National Institute of Environmental Health Sciences (ES000260); PLCO-This research was supported by the Intramural Research Program of the National Cancer Institute and by contracts from the Division of Cancer Prevention, National Cancer Institute, NIH, DHHS; SCALE (K.E.S., H.O.A., H.H.)-Swedish Cancer Society (2009/659). Stockholm County Council (20110209) and the Strategic Research Program in Epidemiology at Karolinska Institute. Swedish Cancer Society grant (02 6661). Danish Cancer Research Foundation Grant. Lundbeck Foundation Grant (R19-A2364). Danish Cancer Society Grant (DP 08-155). National Institutes of Health (5R01 CA69669-02). Plan Denmark; UCSF2 (C.F.S.)-National Institutes of Health RO1CA1046282 and RO1CA154643; (E.A.H., P.M.B.)-The collection of cancer incidence data used in this study was supported by the California Department of Health Services as part of the statewide cancer reporting program mandated by California Health and Safety Code Section 103885; the National Cancer Institute's Surveillance, Epidemiology and End Results Program under contract HHSN261201000140C awarded to the Cancer Prevention Institute of California, contract HHSN261201000035C awarded to the University of Southern California and contract HHSN261201000034C awarded to the Public Health Institute; and the Centers for Disease Control and Prevention's National Program of Cancer Registries, under agreement #1U58 DP000807-01 awarded to the Public Health Institute. The ideas and opinions expressed herein are those of the authors, and endorsement by the State of California, the California Department of Health Services, the National Cancer Institute, or the Centers for Disease Control and Prevention or their contractors and subcontractors is not intended nor should be inferred; WHI-WHI investigators are: Program Office-(National Heart, Lung, and Blood Institute, Bethesda, Maryland) Jacques Rossouw, Shari Ludlam, Dale Burwen, Joan McGowan, Leslie Ford, and Nancy Geller; Clinical Coordinating Center-(Fred Hutchinson Cancer Research Center, Seattle, WA) Garnet Anderson, Ross Prentice, Andrea LaCroix, and Charles Kooperberg; Investigators and Academic Centers-(Brigham and Women's Hospital, Harvard Medical School, Boston, MA) JoAnn E. Manson; (MedStar Health Research Institute/Howard University, Washington, DC) Barbara V. Howard; (Stanford Prevention Research Center, Stanford, CA) Marcia L. Stefanick; (The Ohio State University, Columbus, OH) Rebecca Jackson; (University of Arizona, Tucson/Phoenix, AZ) Cynthia A. Thomson; (University at Buffalo, Buffalo, NY) Jean Wactawski-Wende; (University of Florida, Gainesville/Jacksonville, FL) Marian Limacher; (University of Iowa, Iowa City/Davenport, IA) Robert Wallace; (University of Pittsburgh, Pittsburgh, PA) Lewis Kuller; (Wake Forest University School of Medicine, Winston-Salem, NC) Sally Shumaker; Women's Health Initiative Memory Study-(Wake Forest University School of Medicine, Winston-Salem, NC) Sally Shumaker. The WHI program is funded by the National Heart, Lung and Blood Institute, National Institutes of Health, U.S. Department of Health and Human Services through contracts HHSN268201100046C, HHSN268201100001C, HHSN268201100002C, HHSN268201100003C, HHSN268201100004C and HHSN271201100004C; YALE (T.Z.)-National Cancer Institute (CA62006).