Journal article

Reduced susceptibility to induced seizures in the Neuroligin-3(R451C) mouse model of autism

Elisa L Hill-Yardin, Andrew Argyropoulos, Suzanne Hosie, Gil Rind, Paul Anderson, Anthony J Hannan, Terence J O'Brien



Epilepsy is a common comorbidity in patients with autism spectrum disorder (ASD) and several gene mutations are associated with both of these disorders. In order to determine whether a point mutation in the gene for the synaptic protein, Neuroligin-3 (Nlgn3, R451C), identified in patients with ASD alters seizure susceptibility, we administered the proconvulsant pentylenetetrazole (PTZ) to adult male Neuroligin-3(R451C) (NL3(R451C)) and wild type (WT) mice. It has previously been reported that NL3(R451C) mice show altered inhibitory GABAergic activity in brain regions relevant to epilepsy, including the hippocampus and somatosensory cortex. PTZ administration induces absence-seizures at low d..

View full abstract


Awarded by National Health and Medical Research Council (NHMRC)

Awarded by Australian Research Council (Future Fellowship)

Funding Acknowledgements

This work was supported by a National Health and Medical Research Council (NHMRC) project grant (APP1047674 to A.J.H and E.L.H-Y), the Royal Melbourne Hospital Neuroscience Foundation and the Victorian Government Operational Infrastructure Scheme. A.J.H was supported by the Australian Research Council (Future Fellowship, FT3) and the NHMRC. We thank L. Catalano, N. Taylor, M. Bastias, C. Thomson and A. Hudson for animal care.