Antibody-targeted vaccination to lung dendritic cells generates tissue-resident memory CD8 T cells that are highly protective against influenza virus infection

LM Wakim; J Smith; I Caminschi; MH Lahoud; JA Villadangos

Journal article

Antibody-targeted vaccination to lung dendritic cells generates tissue-resident memory CD8 T cells that are highly protective against influenza virus infection

LM Wakim, J Smith, I Caminschi, MH Lahoud, JA Villadangos

Mucosal Immunology | Published : 2015

DOI: 10.1038/mi.2014.133

Abstract

Influenza virus gains entry into the body by inhalation and initiates its replication cycle within the lung. The early stage of infection, while the virus is confined to the lung mucosa, provides the ideal window of opportunity for an effective immune response to control the infection. Tissue-resident memory (Trm) CD8 T cells, located in a variety of tissues including the lung, are ideally situated to act during this window and stall the infection. The factors involved in the differentiation of lung Trm cells remain poorly defined. We demonstrate that recognition of antigen presented locally by dendritic cells (DCs) and transforming growth factor-β (TGFβ) signaling are both required. We expl..

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University of Melbourne Researchers

Linda Wakim Author

Jeffrey Smith Author Medical Biology (w.e.h.i.)

Jose Villadangos Author

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Grants

Funding Acknowledgements

We thank M. Bevan and N. Zhang for TGF beta RII KO OT-I mice. This work was funded by the National Health and Medical Research Council (NHMRC) of Australia, with additional support from the University of Melbourne (Early Career Establishment Grant) and the Ramaciotti Foundation (to L.M.W.). J.A. Villadangos is a NHMRC Principal Research Fellow and L.M. Wakim is a NHMRC Career Development Fellow.