Journal article

Delineation of the working memory profile in female FMR1 premutation carriers: The effect of cognitive load on ocular motor responses

Annie L Shelton, Kim M Cornish, David E Godler, Meaghan Clough, Claudine Kraan, Bui Minh, Joanne Fielding

BEHAVIOURAL BRAIN RESEARCH | ELSEVIER SCIENCE BV | Published : 2015

Abstract

Fragile X mental retardation 1 (FMR1) premutation carriers (PM-carriers) are characterised as having mid-sized expansions of between 55 and 200 CGG repeats in the 5' untranslated region of the FMR1 gene. While there is evidence of executive dysfunction in PM-carriers, few studies have explicitly explored working memory capabilities in female PM-carriers. 14 female PM-carriers and 13 age- and IQ-matched healthy controls completed an ocular motor n-back working memory paradigm. This task examined working memory ability and the effect of measured increases in cognitive load. Female PM-carriers were found to have attenuated working memory capabilities. Increasing the cognitive load did not elici..

View full abstract