Journal article

Family history of premature coronary heart disease, child cardio-metabolic risk factors and left ventricular mass

Costan G Magnussen, Terence Dwyer, Alison Venn

CARDIOLOGY IN THE YOUNG | CAMBRIDGE UNIV PRESS | Published : 2014

Abstract

In a prospective cohort of 181 individuals followed up since childhood--when aged 9, 12 and 15 years--patients with a family history of premature coronary heart disease (n=18) had higher left ventricular mass index in adulthood--at mean age of 31 years--compared with those without (mean±standard error 39.1±1.9 versus 34.6±0.7 g/m(2.7), p=0.04). The correlation between adult left ventricular mass index and child triglycerides (r=0.66, p=0.04 versus r=-0.03, p=0.75; p(diff)=0.02) and diastolic blood pressure (r=0.65, p=0.02 versus r=0.16, p=0.07; p(diff)=0.05) was stronger among those with a family history of coronary heart disease than in those without. Although preliminary, these data sugges..

View full abstract

Grants

Awarded by National Health and Medical Research Council


Funding Acknowledgements

The Australian Schools Health and Fitness Study was supported by grants from the Commonwealth Departments of Sport, Recreation and Tourism, and Health; The National Heart Foundation; and the Commonwealth Schools Commission. The Childhood Determinants of Adult Health study was supported by grants from the National Health and Medical Research Council; The National Heart Foundation; the Tasmanian Community Fund; and Veolia Environmental Services. CGM holds a National Health and Medical Research Council Early Career Fellowship (Public Health Fellowship, APP1037559).