Journal article

Predictors of treatment response in young people at ultra-high risk for psychosis who received long-chain omega-3 fatty acids

GP Amminger, A Mechelli, S Rice, S-W Kim, CM Klier, RK McNamara, M Berk, PD McGorry, MR Schaefer

TRANSLATIONAL PSYCHIATRY | NATURE PUBLISHING GROUP | Published : 2015

Abstract

Previous efforts in the prospective evaluation of individuals who experience attenuated psychotic symptoms have attempted to isolate mechanisms underlying the onset of full-threshold psychotic illness. In contrast, there has been little research investigating specific predictors of positive outcomes. In this study, we sought to determine biological and clinical factors associated with treatment response, here indexed by functional improvement in a pre-post examination of a 12-week randomized controlled intervention in individuals at ultra-high risk (UHR) for psychosis. Participants received either long-chain omega-3 (ω-3) polyunsaturated fatty acids (PUFAs) or placebo. To allow the determina..

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Grants

Awarded by Stanley Medical Research Institute


Awarded by NHMRC Senior Research Fellowship


Awarded by NHMRC Senior Principal Research Fellowship


Funding Acknowledgements

This work was supported by grants from the Stanley Medical Research Institute (03T-315, 07TGF-1102). GPA is supported by a NHMRC Senior Research Fellowship 1080963. MB is supported by a NHMRC Senior Principal Research Fellowship 1059660. PDM is supported by a NHMRC Senior Research Fellowship 1060996.