Journal article

Cancer immunotherapy utilizing gene-modified T cells: From the bench to the clinic

Connie PM Duong, Carmen SM Yong, Michael H Kershaw, Clare Y Slaney, Phillip K Darcy



The immune system plays a critical role in the elimination and suppression of pathogens. Although the endogenous immune system is capable of immune surveillance resulting in the elimination of cancer cells, tumor cells have developed a variety of mechanisms to escape immune recognition often resulting in tumor outgrowth. The presence of immune infiltrate in tumors has been correlated with a good prognosis following treatment (Sato et al., 2005; Loi et al., 2013; Clemente et al., 1996; Galon et al., 2006). As such, immune cells such as T cells, have been harnessed in order to target cancer. Tumor reactive lymphocytes, called tumor-infiltrating lymphocytes (TILs) have been isolated and expande..

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Awarded by National Health and Medical Research Council (NHMRC)

Awarded by National Breast Cancer Fellowship

Awarded by National Breast Cancer Foundation

Funding Acknowledgements

This work was funded by Program and Project grants from the National Health and Medical Research Council (NHMRC) (#1013667, #1030436). C. Y. Slaney was supported by a National Breast Cancer Fellowship (#PF-12-14). P. K. Darcy and M. H. Kershaw were supported by NHMRC Senior Research Fellowships (#1041828 and 1058388 respectively).