The association between use of antidepressants and bone quality using quantitative heel ultrasound
Paivi H Rauma, Julie A Pasco, Michael Berk, Amanda L Stuart, Heli Koivumaa-Honkanen, Risto J Honkanen, Jason M Hodge, Lana J Williams
Australian & New Zealand Journal of Psychiatry | SAGE PUBLICATIONS LTD | Published : 2015
OBJECTIVE: Osteoporosis and depression are major public health problems worldwide. Studies have reported an association between antidepressant use, mainly selective serotonin reuptake inhibitors (SSRIs), and bone mineral density (BMD), but the issue remains unclear. METHODS: This study examined data collected from 849 Australian men (aged 24-98 years) participating in the Geelong Osteoporosis Study (GOS). Bone quality was determined using quantitative ultrasound (QUS) and included the following parameters: Broadband Ultrasound Attenuation (BUA), Speed of Sound (SOS) and Stiffness Index (SI). Anthropometry, socio-economic status (SES), medication use and lifestyle factors were determined. The..View full abstract
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Awarded by National Health and Medical Research Council
Awarded by NHMRC
The GOS is supported by grants from the National Health and Medical Research Council (NHMRC 299831 and 628582). PHR received a travel grant and research support from the Saastamoinen Foundation, research support from National Doctoral Programme of Musculoskeletal Disorders and Biomaterials, Finnish Concordia Fund, North Savo Regional Fund of Finnish Cultural Foundation and an EVO grant from Lapland Hospital District. MB is supported by a NHMRC Senior Principal Research Fellowship (1059660). HK-H and RJH received an EVO grant from Lapland Hospital District. JMH are supported by a NHMRC. LJW is supported by a NHMRC Career Development Fellowship (1064272).