Journal article
Association of the colorectal CpG island methylator phenotype with molecular features, risk factors, and family history
DJ Weisenberger, AJ Levine, TI Long, DD Buchanan, R Walters, M Clendenning, C Rosty, AD Joshi, MC Stern, L Le Marchand, NM Lindor, D Daftary, S Gallinger, T Selander, B Bapat, PA Newcomb, PT Campbell, G Casey, DJ Ahnen, JA Baron Show all
Cancer Epidemiology Biomarkers and Prevention | Published : 2015
Abstract
Background: The CpG island methylator phenotype (CIMP) represents a subset of colorectal cancers characterized by widespread aberrant DNA hypermethylation at select CpG islands. The risk factors and environmental exposures contributing to etiologic heterogeneity between CIMP and non-CIMP tumors are not known. Methods: We measured the CIMP status of 3,119 primary population-based colorectal cancer tumors from the multinational Colon Cancer Family Registry. Etiologic heterogeneity was assessed by a case-case study comparing risk factor frequency of colorectal cancer cases with CIMP and non-CIMP tumors using logistic regression to estimate the case-case odds ratio (ccOR). Results: We found asso..
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Awarded by National Institutes of Health
Funding Acknowledgements
This work was supported by NIH/NCI grant R01 CA118699 (to P.W. Laird) and R01 HG006705 (to K.D. Siegmund). This work was also supported by grant UM1 CA167551 (to R.W. Haile, M.A. Jenkins, N.M. Lindor) from the National Cancer Institute and through the cooperative agreements with the following CCFR centers: Australasian Colorectal Cancer Family Registry (U01 CA074778; to J.R. Jass) and (U01/U24 CA097735; to J.L. Hopper), USC Consortium Colorectal Cancer Family Registry (U01/U24 CA074799; to R.W. Haile), Mayo Clinic Cooperative Family Registry for Colon Cancer Studies (U01/U24 CA074800; to N.L. Lindor), Ontario Registry for Studies of Familial Colorectal Cancer (U01/U24 CA074783; to S. Gallinger), Seattle Colorectal Cancer Family Registry (U01/U24 CA074794; to J.D. Potter and P.A. Newcomb), and University of Hawaii Colorectal Cancer Family Registry (U01/U24 CA074806; to L. Le Marchand). The Jeremy Jass Memorial Pathology Bank provided CCFR paraffin-embedded tissue and pathology-related variables for this study.