Developmental kinetics of cleavage stage mouse embryos are related to their subsequent carbohydrate and amino acid utilization at the blastocyst stage

Abstract

study question: What is the relationship between cleavage stage embryo kinetics, blastocyst metabolism and subsequent embryo viability? summaryanswer: Embryos cleaving faster at the first cleavage division resulted in blastocysts with a larger inner cell mass (ICM), higher glucose consumption, lower glycolytic rate, higher aspartate uptake, lower global amino acid turnoverand higher percentage of developing fetuses on E13.5 when compared with blastocysts that developed from slower cleaving embryos. what is known already: Previous research has shown that morphokinetics, blastocyst carbohydrate metabolism and cleavage stage amino acidmetabolismof the preimplantationembryocanbe used independent..