Journal article

Recurrent and second primary squamous cell carcinoma of the head and neck: When and how to reirradiate

Primoz Strojan, June Corry, Avraham Eisbruch, Jan B Vermorken, William M Mendenhall, Anne WM Lee, Missak Haigentz, Jonathan J Beitler, Remco de Bree, Robert P Takes, Vinidh Paleri, Charles G Kelly, Eric M Genden, Carol R Bradford, Louis B Harrison, Alessandra Rinaldo, Alfio Ferlito

Head & Neck | WILEY | Published : 2015


BACKGROUND: Local and/or regional recurrence and metachronous primary tumor arising in a previously irradiated area are rather frequent events in patients with head and neck squamous cell carcinoma (HNSCC). Re-treatment is associated with an increased risk of serious toxicity and impaired quality of life (QOL) with an uncertain survival advantage. METHODS: We analyzed the literature on the efficacy and toxicity of photon/electron-based external beam reirradiation for previously irradiated patients with HNSCC of non-nasopharyngeal origin. Studies were grouped according to the radiotherapy technique used for reirradiation. Patient selection criteria, target volume identification method, tumor ..

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University of Melbourne Researchers