Journal article

Systems genetics identifies Sestrin 3 as a regulator of a proconvulsant gene network in human epileptic hippocampus

Michael R Johnson, Jacques Behmoaras, Leonardo Bottolo, Michelle L Krishnan, Katharina Pernhorst, Paola L Meza Santoscoy, Tiziana Rossetti, Doug Speed, Prashant K Srivastava, Marc Chadeau-Hyam, Nabil Hajji, Aleksandra Dabrowska, Maxime Rotival, Banafsheh Razzaghi, Stjepana Kovac, Klaus Wanisch, Federico W Grillo, Anna Slaviero, Sarah R Langley, Kirill Shkura Show all

Nature Communications | NATURE PUBLISHING GROUP | Published : 2015

Grants

Awarded by National Genome Research Network (NGFNplus: EMINet)


Awarded by DFG


Awarded by BMBF


Awarded by Wellcome Trust


Awarded by European Union's Seventh Framework Programme (FP7)


Awarded by Lundbeck Foundation


Awarded by Medical Research Council


Funding Acknowledgements

We acknowledge funding from Imperial NIHR Biomedical Research Centre/Imperial Innovations (E.P., J.B., M.R.J.), National Genome Research Network (NGFNplus: EMINet, grant 01GS08122; S.S., A.J.B.), DFG (SFB1089; A.J.B.), DFG (KFO177/SFB-1089; A.J.B., S.S.), BMBF (01GQ0806, S.S.), GIF (A.J.B.), ESF EuroEpinomics (A.J.B.), Else-Kroner Fresenius Foundation (A.J.B.), Wellcome Trust (J.B.), Imperial College Junior research fellowship (J.B.) and BONFOR (S.S., A.J.B.), UCB Pharma (M.R.J., E.P., R.K.), Medical Research Council UK (E.P.), CONACYT, Mexico (P.L.M.S., V.T.C.), Imperial College/Imperial College Healthcare, who received a proportion of funding from the Department of Health's NIHR Biomedical Research Centres (BRC) funding scheme (M.R.J., E.P.). DNA collection for GWAS was part funded by the Wellcome Trust (M.R.J., Grant Reference WT066056). The research leading to these results has received funding from the European Union's Seventh Framework Programme (FP7/2007-2013) under grant agreement no. 602102 (EPITARGET; M.R.J., S.S., M.S., A.J.B., E.P.). The research was supported by the National Institute for Health Research (NIHR) Imperial Biomedical Research Centre (M.R.J., E.P.). The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health. We thank Mario Falchi and Philippe Froguel for providing critical comments on the first version of the manuscript.