Effects of selective beta 1-adrenoceptor blockade on cardiovascular and renal function and circulating cytokines in ovine hyperdynamic sepsis
Paolo Calzavacca, Yugeesh R Lankadeva, Simon R Bailey, Michael Bailey, Rinaldo Bellomo, Clive N May
Critical Care (UK) | BMC | Published : 2014
INTRODUCTION: Activation of the sympathetic nervous system has beneficial cardiovascular effects in sepsis, but there is also evidence that sympatholytics have beneficial actions in sepsis. We therefore determined the effect of selective β1-adrenoceptor blockade on cardiac and renal function and cytokine release in ovine hyperdynamic sepsis. METHODS: Hyperdynamic sepsis was induced by infusion of live E. coli for 24 hours in nine conscious sheep instrumented with flow probes on the pulmonary and left renal artery. Cardiovascular and renal function and levels of plasma cytokines were determined in a control group and during selective β1-adrenoceptor blockade with atenolol (10 mg intravenous b..View full abstract
The authors would like to acknowledge the expert technical assistance of Alan McDonald and Tony Dornom. This study was supported by grants from the National Health and Medical Research Council of Australia (NHMRC) and by funding from the Victorian Government Operational Infrastructure Support Grant. CNM was supported by a NHMRC Research Fellowship, and PC was supported by an International Postgraduate Student Scholarship from the University of Melbourne.