Renal Dysfunction is Associated with a Reduced Contribution of Nitric Oxide and Enhanced Vasoconstriction Following a Congenital Renal Mass Reduction in Sheep

Abstract

© 2014 by the American College of Cardiology Foundation and the American Heart Association, Inc. BACKGROUND—: Children born with reduced congenital renal mass have increased risk of hypertension and chronic kidney disease in adulthood, though mechanisms are poorly understood. Similar sequelae occur following fetal uninephrectomy (uni-x) in sheep leading to a 30% nephron deficit. We hypothesized that renal dysfunction is underpinned by a reduced contribution of nitric oxide (NO) and vascular dysfunction in uni-x sheep.METHODS AND RESULTS—: In 5-year old female uni-x and sham sheep, mean arterial pressure (MAP), glomerular filtration rate (GFR) and renal blood flow (RBF) were measured before ..