Spinal cord injury increases the reactivity of rat tail artery to angiotensin II

H Al Dera; JA Brock

Journal article

Spinal cord injury increases the reactivity of rat tail artery to angiotensin II

H Al Dera, JA Brock

Frontiers in Neuroscience | Published : 2015

DOI: 10.3389/fnins.2014.00435

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Abstract

Studies in individuals with spinal cord injury (SCI) suggest the vasculature is hyperreactive to angiotensin II (Ang II). In the present study, the effects of SCI on the reactivity of the rat tail and mesenteric arteries to Ang II have been investigated. In addition, the effects of SCI on the facilitatory action of Ang II on nerve-evoked contractions of these vessels were determined. Isometric contractions of artery segments from T11 (tail artery) or T4 (mesenteric arteries) spinal cord-transected rats and sham-operated rats were compared 6-7 weeks postoperatively. In both tail and mesenteric arteries, SCI increased nerve-evoked contractions. In tail arteries, SCI also greatly increased Ang ..

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University of Melbourne Researchers

James Brock Author

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Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

This work was supported by grants from the NHMRC (Grant ID APP1024485) and the Transport Accident Commission (Victoria). Hussain Al Dera was supported by a postgraduate award from King Saud Bin Abdulaziz University for Health Science, College of Medicine (Riyadh, Saudi Arabia).