Journal article

Simian immunodeficiency virus infection and immune responses in the pig-tailed macaque testis

Wendy R Winnall, Sarah B Lloyd, Robert De Rose, Sheilajen Alcantara, Thakshila H Amarasena, Mark P Hedger, Jane E Girling, Stephen J Kent

JOURNAL OF LEUKOCYTE BIOLOGY | FEDERATION AMER SOC EXP BIOL | Published : 2015

Abstract

The testis is a site of immune privilege in rodents, and there is evidence that T cell responses are also suppressed in the primate testis. Local immunosuppression is a potential mechanism for HIV persistence in tissue reservoirs that few studies have examined. The response of the pig-tailed macaque testis to SIVmac239 infection was characterized to test this possibility. Testes were surgically removed during early-chronic (10 wk) and late-chronic (24-30 wk) SIV infection in 4 animals and compared with those from 7 uninfected animals. SIV infection caused only minor disruption to the seminiferous epithelium without marked evidence of inflammation or consistent changes in total intratesticula..

View full abstract

Grants

Awarded by Australian National Health and Medical Research Council (NHMRC)


Awarded by NHMRC Program Grant


Funding Acknowledgements

This work was supported by Australian National Health and Medical Research Council (NHMRC) fellowships (1013221, 1041832, 1020269, and 1011578), NHMRC Program Grant 1052979, and the Victorian government's Operational Infrastructure Support Program. The authors thank Hyon-Xhi Tan, Shayarana Gooneratne, Marit Kramski, Caroline Fernandez Megan Schepers, and Lisa Reid for technical assistance. The authors also thank the staff of the Biomedical Science Histology Facility (University of Melbourne) and the Royal Melbourne Hospital Tissue Bank for expert tecnical assistance.