Journal article

Myocardial and Cardiomyocyte Stress Resilience Is Enhanced in Aromatase-Deficient Female Mouse Hearts Through CaMKII delta Activation

James R Bell, Gabriel B Bernasochi, Amanda C Wollermann, Antonia JA Raaijmakers, Wah Chin Boon, Evan R Simpson, Claire L Curl, Kimberley M Mellor, Lea MD Delbridge

ENDOCRINOLOGY | ENDOCRINE SOC | Published : 2015

Abstract

The role of sex steroids in cardioprotection is contentious, with large clinical trials investigating hormone supplementation failing to deliver outcomes expected from observational studies. Mechanistic understanding of androgen/estrogen myocardial actions is lacking. Using a genetic model of aromatase tissue deficiency (ArKO) in female mice, the goal of this investigation was to evaluate the capacity of a shift in cardiac endogenous steroid conversion to influence ischemia-reperfusion resilience by optimizing cardiomyocyte Ca2+ handling responses. In isolated normoxic cardiomyocytes, basal Ca2+ transient amplitude and extent of shortening were greater in ArKO myocytes, with preservation of ..

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