Journal article
A genetic variant regulating miR-126 is associated with sight threatening diabetic retinopathy
AK McAuley, M Dirani, JJ Wang, PP Connell, EL Lamoureux, AW Hewitt
Diabetes and Vascular Disease Research | SAGE PUBLICATIONS LTD | Published : 2015
Abstract
Background: The regulation of miR-126 by rs4636297 single nucleotide polymorphism (SNP) has been implicated in the pathogenesis of neovascularisation by promoting vascular endothelial growth factor, suggesting it could be associated with sight threatening diabetic retinopathy (STDR), but has not been previously investigated or reported. Materials and methods: A case control study of 531 individuals with diabetes was genotyped for the rs4636297 SNP, using the Sequenom iPLEX Gold chemistry. STDR included people with severe non-proliferative diabetic retinopathy (NPDR) or proliferative diabetic retinopathy (PDR). Association was tested using logistic regression analysis, adjusting for confoundi..
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Awarded by Diabetes Australia Research Trust
Funding Acknowledgements
This research was supported by the Brownless Perpetual Charitable Trust, the Joan and Peter Clemenger Trust, the Diabetes Australia Research Trust, and a National Health and Medical Research Council Centre for Clinical Research Excellence grant Translational Clinical Research in Major Eye Diseases (# 529923). A.K.M. is supported by Australian National Health and Medical Research Council Postgraduate Scholarship (# 590231). J.J.W., E.L. and A.W.H. are supported by National Health and Medical Research Council Fellowships (# 632909, # 1045280 and # 1037838, respectively). The Centre for Eye Research Australia receives Operational Infrastructure Support from the Victorian Government.