Measurement of Fecal Calprotectin Improves Monitoring and Detection of Recurrence of Crohn's Disease After Surgery
Emily K Wright, Michael A Kamm, Peter De Cruz, Amy L Hamilton, Kathryn J Ritchie, Efrosinia O Krejany, Steven Leach, Alexandra Gorelik, Danny Liew, Lani Prideaux, Ian C Lawrance, Jane M Andrews, Peter A Bampton, Simon L Jakobovits, Timothy H Florin, Peter R Gibson, Henry Debinski, Finlay A Macrae, Douglas Samuel, Ian Kronborg Show all
GASTROENTEROLOGY | W B SAUNDERS CO-ELSEVIER INC | Published : 2015
BACKGROUND & AIMS: Crohn's disease (CD) usually recurs after intestinal resection; postoperative endoscopic monitoring and tailored treatment can reduce the chance of recurrence. We investigated whether monitoring levels of fecal calprotectin (FC) can substitute for endoscopic analysis of the mucosa. METHODS: We analyzed data collected from 135 participants in a prospective, randomized, controlled trial, performed at 17 hospitals in Australia and 1 hospital in New Zealand, that assessed the ability of endoscopic evaluations and step-up treatment to prevent CD recurrence after surgery. Levels of FC, serum levels of C-reactive protein (CRP), and Crohn's disease activity index (CDAI) scores wer..View full abstract
Research support was provided by the St Vincent's Research Endowment Fund; Smart-Prep testing kits were provided by Bulhmann; and supported by the National Health and Medical Research Council (E.W., P.D.C., and M.A.K.).